A lower X-gate in TASK channels traps inhibitors within the vestibule

A lower X-gate in TASK channels traps inhibitors within the vestibule

Nature, Published online: 29 April 2020; doi:10.1038/s41586-020-2250-8

The X-ray crystal structure of the potassium channel TASK-1 reveals the presence of an X-gate, which traps small-molecule inhibitors in the intramembrane vestibule and explains their low washout rates from the channel.
Source: Nature

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