Caspase-7 activates ASM to repair gasdermin and perforin pores
Nature, Published online: 15 June 2022; doi:10.1038/s41586-022-04825-8
Caspase-7 cleaves and activates acid sphingomyelinase (ASM), which promotes the repair of gasdermin pores and thereby delays pore-driven lysis to allow other processes such as extrusion or apoptosis to occur before cell death.
Source: Nature