IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

Nature, Published online: 23 December 2020; doi:10.1038/s41586-020-03074-x

A class of compounds with a dual mechanism of action—direct targeting of IspH and stimulation of cytotoxic γδ T cells to enhance pathogen clearance—are active against multidrug-resistant bacteria.
Source: Nature

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