Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Nature, Published online: 20 January 2021; doi:10.1038/s41586-020-03160-0

In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.
Source: Nature

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