NEW YORK (AP) — A computer outage at the Federal Aviation Administration brought flights to a standstill across the U.S. on Wednesday, with hundreds of delays quickly cascading through the system at airports nationwide.

The FAA ordered all U.S. flights to delay departures until 9 a.m. Eastern, though airlines said they were aware of the situation and had already begun grounding flights.

At 8 a.m. Eastern, there were more than 2,500 delayed flights within, into or out of the United States, according to the flight tracking website FlightAware, exceeding the number of all delayed flights on the previous day. More than 150 have been cancelled.

Those numbers are likely to grow.

More than 21,000 flights were scheduled to take off in the U.S. today, mostly domestic trips, and about 1,840 international flights expected to fly to the U.S., according to aviation data firm Cirium.

The White House said that there is no evidence of a cyberattack, but President Joe Biden directed the Department of Transportation to investigate the cause of the disruption.

President Joe Biden addressed the FAA issue Wednesday before leaving the White House. He said he had just been briefed by Transportation Secretary Pete Buttigieg, who told him they still had not identified what went wrong.

“I just spoke to Buttigieg. They don’t know what the cause is. But I was on the phone with him about 10 minutes,” Biden said. “I told him to report directly to me when they find out. Air traffic can still land safely, just not take off right now. We don’t know what the cause of it is.”

Buttigieg said in a tweet that he is in touch with the FAA and monitoring the situation.

Most delays were concentrated along the East Coast, but were beginning to spread west. Inbound international flights into Miami International Airport continued to land, but all departures have been delayed since 6:30 a.m., said airport spokesman Greg Chin.

The FAA said it was working on restoring its Notice to Air Missions System.

“We are performing final validation checks and reloading the system now,” the FAA said. “Operations across the National Airspace System are affected.”

The agency said that some functions are beginning to come back on line, but that “National Airspace System operations remain limited.”

United Airlines said that it had temporarily delayed all domestic flights and would issue an update once it learned more from the FAA. American Airlines said that it was closely monitoring the situation.

Julia Macpherson was on a United Airlines flight from Sydney to Los Angeles on Wednesday when she learned of possible delays.

“As I was up in the air I got news from my friend who was also traveling overseas that there was a power outage,” said Macpherson, who was returning to Florida from Hobart, Tasmania. Once she lands in Los Angeles, she still has a connection in Denver on her flight to Jacksonville, Florida.

She said there have been no announcements on the flight about the FAA issue.

Macpherson said she had already experienced a delay in her travels because her original flight from Melbourne to San Francisco was canceled and she rebooked a flight from Sydney to Los Angeles.

The FAA is working to restore what is known as the Notice to Air Missions System.

Before commencing a flight, pilots are required to consult NOTAMs, or Notices to Air Missions, which list potential adverse impacts on flights, from runway construction to the potential for icing. The system used to be telephone-based, with pilots calling dedicated flight service stations for the information, but has now moved online.

There is a potential for widespread disruption because of the outage. All aircraft are required to route through the system, including commercial and military flights.

European flights into the U.S. appeared to be largely unaffected.

Irish carrier Aer Lingus said services to the U.S. continue, and Dublin Airport’s website showed that its flights to Newark, Boston, Chicago and Los Angeles were running on schedule.

“Aer Lingus plan to operate all transatlantic flights as scheduled today,” the carrier said in a prepared statement. “We will continue to monitor but we do not anticipate any disruption to our services arising from the technical issue in the United States.”

The FAA said that it would provide frequent updates as it made progress.

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AP White House Correspondent Zeke Miller contributed to this report from Washington, D.C. AP Business Writer Kelvin Chan contributed from London. AP reporter Freida Frisaro contributed from Miami. AP Airlines Writer David Koenig contributed from Dallas.